Barr Pharmaceuticals
Current as of: November 21, 2007
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Generic Name: Thalidomide
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Thalidomide is an antiangiogenic compound that blocks certain growth factors such asvascular endothelial growth factor (VEGF) and bFGF.
Administration Route: PO
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• cutaneous manifestations of moderate to severe erythema nodosum leprosum (ENL) in leprosy
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BioAlliance Pharma
Affiliate(s):
· Par Pharmaceutical
Current as of: December 04, 2007
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Generic Name: Miconazole
Brand Name: Loramyc •
Miconazole Lauriad
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Loramyc comprises miconazole, an antifungal agent with broad-spectrum activity against various species of Candida, formulated with the Lauriad extended release tablet delivery platform (miconazole Lauriad bioadhesive buccal tablet).
Administration Route: PO
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• oropharyngeal candidiasis in immunocompromized patients, particularly those with head and neck cancer treated with radiotherapy, and those infected with HIV
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GlaxoSmithKline
Affiliate(s):
· University of Florida Gainsville
Current as of: December 02, 2007
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Generic Name: Topotecan
Brand Name: Hycamtin, Hycaptamine
Other Designation: NSC-609699, SK&F-104864
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Topotecan, a water-soluble camptothecin analog, is a topoisomerase I inhibitor.
Administration Route: intravenous (IV) •
PO •
intracerebral
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• ovarian cancer, metastatic, second or third line-IV
• small cell lung cancer (sclc), refractory, second line treatment-IV
• small cell lung cancer (sclc), relapsed, when retreatment with the first line regimen is not considered appropriate, IV
• cervical cancer, Stage IVb recurrent or persistent not amenable to curative treatment with surgery and/or radiation therapy, in combination with cisplatin-IV
• small cell lung cancer (sclc), relapsed-PO
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PharmaMar
Affiliate(s):
· Ortho Biotech Products
· University of Illinois
· Genesis Pharma
Current as of: December 02, 2007
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Generic Name: Trabectedin
Brand Name: Yondelis
Other Designation: Ecteinascidin 743, ET-743, NSC 648766
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Trabectedin, a novel marine compound derived from the tunicate Ecteinascidia turbinata, is a cytotoxic alkaloid and a DNA minor groove, guanine-specific interacting agent that also targets topo I, inducing topo I-mediated protein-linked DNA breaks.
Administration Route: intravenous (IV), intermittent •
intravenous (IV), continuous
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• soft tissue sarcoma, refractory to standard treatments
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